RIJAL LAB

Publications

2026

  1. Tennakoon A, Edirisingha IK, Rutledge E, Bhattacharyya A, King E, Moresi M, Lovings A, Yarborough PR, Hoben A, Manns G, Gibson TR Jr, Uddin SMA, Bae Y, Taylor N, Johnson TL, Futral M, Wilson P, Brown J, Arbogast ZL, Brooks A, Ward C, Foxworth C, Nguyen K, Fairchild D, Lemus D, White H, Craft H, Adonis J, Givan K, Valdivia S, Wallace KB, Bent M, Mavrodi D, Heller DM, Rijal R*. Identification of novel inhibitors of Mycobacterium smegmatis growth through genome-wide overexpression of Cluster P3 mycobacteriophage Xavia genes. *Corresponding author. bioRxiv 2026. Preprint
  2. Uddin, S.Z.; Rijal, R.; Pilling, D.; Gomer, R.H. Phosphoproteomic Profiling Reveals Overlapping and Distinct Signaling Pathways in Dictyostelium discoideum in Response to Two Different Chemorepellents. Cells 2026, 15, 60. PMCID: PMC12633543

2025

  1. Rijal R* and Gomer RH. Pharmacological inhibition of host pathways enhances macrophage killing of intracellular bacterial pathogens. *Corresponding author. Microbiol Spectr. 2025 Dec 3:e0216325. PMCID: PMC12772234.
  2. El-Sobky MH, Rijal R, Gomer RH. Two endogenous Dictyostelium discoideum chemorepellents use different mechanisms to induce repulsion. Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2503168122. doi: 10.1073/pnas.2503168122. Epub 2025 May 27. PMCID: PMC12146723.

2024

  1. Rijal R and Gomer RH. Proteomic analysis of Dictyostelium discoideum by mass spectrometry. (Invited book chapter). Methods Mol Biol. 2024:2814:247-255. PMCID: PMC11414281
  2. Consalvo KM*, Rijal R*, Beruvides SL, Mitchell R, Beauchemin K, Collins D, Scoggin J, Scott J, and Gomer RH. Elucidating the roles of PTEN and PTEN-like phosphatase CnrN during eukaryotic chemorepulsion. *Co-first authors. J Cell Sci. 2024 Aug 1;137(15):jcs262054. PMCID: PMC11317092
  3. Rijal R* and Gomer RH*. Gallein potentiates isoniazid’s ability to suppress Mycobacterium tuberculosis growth. *Corresponding authors. Front. Microbiol. 2024 Apr 15:15:1369763. PMCID: PMC11060752

2023

  1. Rahman RJ, Rijal R*, Jing S, Chen TA, Ismail I, and Gomer RH. Polyphosphate uses mTOR, pyrophosphate, and Rho GTPase components to potentiate bacterial survival in Dictyostelium. *Mentored and supervised. mBio. 2023 Sep 27;e0193923. PMCID:PMC10653871
  2. Rijal R*, Ismail I, Jing S, and Gomer RH. Starvation induces extracellular accumulation of polyphosphate in Dictyostelium discoideum to inhibit macropinocytosis, phagocytosis, and exocytosis. *Corresponding author. Int J Mol Sci. 2023 Mar 21; 24(6), 5923. PMCID: PMC10056890

2022

  1. Rijal R, Kirolos SA, Rahman RJ, Gomer RH. Dictyostelium discoideum cells retain nutrients when the cells are about to overgrow their food source. J Cell Sci. 2022 Aug 26; jcs.260107. PMCID: PMC9592050
  2. Kirolos SA, Procaccia SR, Groover KE, Das R, Rijal R, and Gomer RH. Identification of novel proteins in the Dictyostelium discoideum chemorepulsion pathway using REMI. MicroPubl Biol. 2022 May 5:10.17912. PMCID: PMC9073555

2021

  1. Riehl J, Rijal R, Clemen CS, Hofmann A, Eichinger L. Domain organisation of the UBX domain containing protein 9 (UBXD9) and analysis of its interactions with the homohexameric AAA+ ATPase p97 (VCP). Front Cell Dev Biol. 2021 Sep 23;9:748860. PMCID: PMC8495200
  2. Kirolos SA, Rijal R, Consalvo KM, Gomer RH. Using Dictyostelium to develop therapeutics for acute respiratory distress syndrome. Front Cell Dev Biol. 2021 Jul 19;9:710005. PMCID: PMC8326840
  3. Tang Y, Rijal R, Zimmerhanzel DE, McCullough JR, Cadena LA, Gomer RH. An Autocrine Negative Feedback Loop Inhibits D. discoideum Proliferation Through Pathways Including IP3/ Ca2+. mBio. 2021 Jun 29;12(3):e0134721. PMCID: PMC8262924

2020

  1. Rijal R, Cadena LA, Smith MR, Carr JF, Gomer RH. Polyphosphate is an extracellular signal that can facilitate bacterial survival in eukaryotic cells. Proc Natl Acad Sci U S A. 2020 Dec 15;117(50):31923-31934. PMCID: PMC7749317
  2. Karow M, Fischer S, Meßling S, Konertz R, Riehl J, Xiong Qiuhong, Rijal R, Wagle P, Clemen CS, Eichinger Ludwig. Functional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum. Cells. 2020 May 9;9(5):1179. PMCID: PMC7290328

2019

  1. Fischer S, Rijal R, Frommolt P, Wagle P, Konertz R, Faix J, Meßling S, Eichinger L. Functional Characterization of Ubiquitin-Like Core Autophagy Protein ATG12 in Dictyostelium discoideum. Cells. 2019 Jan 19;8(1). PMCID: PMC6356199
  2. Consalvo KM, Rijal R, Tang Y, Kirolos SA, Smith MR, Gomer RH. Extracellular signaling in Dictyostelium. Int J Dev Biol. 2019;63(8-9-10):395-405. PMCID: PMC6986813
  3. Rijal R, Consalvo KM, Lindsey CK, Gomer RH. An endogenous chemorepellent directs cell movement by inhibiting pseudopods at one side of cells. Mol Biol Cell. 2019 Jan 15;30(2):242-255. PMCID: PMC6589559

2018

  1. Song L, Rijal R, Karow M, Stumpf M, Hahn O, Park L, Insall R, Schröder R, Hofmann A, Clemen CS, Eichinger L. Expression of N471D strumpellin leads to defects in the endolysosomal system. Dis Model Mech. 2018 Sep 13;11(9). PMCID: PMC6177004

2016

  1. Rijal R, Arhzaouy K, Strucksberg KH, Cross M, Hofmann A, Schröder R, Clemen CS, Eichinger L. Mutant p97 exhibits species-specific changes of its ATPase activity and compromises the UBXD9-mediated monomerisation of p97 hexamers. Eur J Cell Biol. 2016 Jun-Jul;95(6-7):195-207. PMID: 27132113

Pubmed

Patents

  1. Richard H. Gomer, Ramesh Rijal, Ryan J. Rahman. Methods for Activating Immune Cells to Kill Bacteria. Application# PCT/US2024/013914